Basic Information
VIS ID
TVIS10017815
Fusion event
HBV-chr21 integration
Validated
No
Detection method
TS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26867494
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
DQ089769.1
Region type
X protein;Polymerase;
Start
1508
Integrated sequence
GCGGGACGTCCTTTGTCTACGTCCCGTCGGCGCTGAATCCCGCGGACGACCCGTCTCGGGGCCGTTTGGGACTCTACCGTCCCCTTCTTCGTCTGCCGTT| |CCGGCCGACCACGGGGCGCACCTCTCTTTACGCGGTCTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCA
Host Sequence
Chromosome
chr21
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
40721226/39349300 (Hg38)
End
40721226/39349300 (Hg38)
Location type
upstream
Nearest miRNA
hsa-let-7c/Upstream/3628492; hsa-mir-3197/Downstream/97710;
Nearest TSS
ENST00000624081/Upstream/100; ENST00000442773/Downstream/44;
Nearest CpG islands
chr21-CpG: 137/Target, None/Upstream, None/Downstream
Nearby gene
HMGN1(+) ;
Upstream sequence
CCGCGCCCGGAATAGGTGAGGCGGGCCCTTAATTGATCCCGGACCCCGCCCCCTTccgggggccccccccccccccccgggcgcccccACCCCTTTCCGC
Downstream sequence
CGTCTCGCGGGGCCCCAGACCCAGGCGAAGGGGGCGGGGTCCCAGTGGCGCTCCGGCCTCACGGTAGTTTGAAGCCGAGCCGCAAAGTGCGGTCTGCGCG
Reference
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.
Curate