Basic Information
VIS ID
TVIS10017824
Fusion event
HBV-MIR548AJ2 integration
Validated
No
Detection method
TS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26867494
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
DQ089769.1
Region type
core protein;X protein;
Start
1829
Integrated sequence
CTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTGGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACC| |TCTGCCTAATCATCTCATGTTCATGTCCCACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGG
Host Sequence
Chromosome
chr4
Cytoband
p15.2
Reference genome
GRCh37/hg19
Start
23427263/23425640 (Hg38)
End
23427263/23425640 (Hg38)
Location type
ncRNA
Fragile sites / regions
FRA4D
Target gene
MIR548AJ2
Nearest miRNA
hsa-mir-12113/Upstream/910255; hsa-mir-1243/Downstream/1094552;
Nearest TSS
ENST00000502981/Upstream/140067; ENST00000499715/Downstream/135283;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/909215, chr4-CpG: 266/Downstream/1044437
Upstream sequence
GGCAGGAAATGGGATCCATATAAACAGGGATTTGGAAATGTTGCAACCAACACAGATGGGAAGAATTACTGTGGCCTACCAGGTAACGAACAGGCATGCA
Downstream sequence
GAATAAATCAAAGTACCAAGAATAAGAAATACAAGCCTCTCCCAGGACTTTAAATCTTGGAAAGAGTAAAACAATTACCAAAATAAATTTTAAAATAGAA
Reference
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.
Curate