Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017826
Fusion event
HBV-ALB integration
Validated
No
Detection method
TS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
Region type
pre-S1/pre-S2/S;Polymerase;
Start
611
Integrated sequence
CCATGCAAGACCTGCACGATTCCTGCTCAAGGAACCTCTATGTTTCCCTCGTGTTGCTGTACAAAACCTTCGGACGGAAATTGCACTTGTATTCCCATCC| |CATCATCTTGGGCTTTCGCAAGATTCCTATGGGAGTGGGCCTCAGTCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCT
Host Sequence
Chromosome
chr4
Cytoband
q13.3
Reference genome
Start
End
74275249/73409532 (Hg38)
Location type
Intronic
Target gene
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-12113/Upstream/7132604; hsa-mir-1243/Downstream/3164036;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/150119, chr4-CpG: 20/Downstream/210795
Upstream sequence
TTTCCCAAAATTTTATTTTTGGTGAGATTTTATTTTGTTTTTCTTTTAGGTGAATATTGGCTTGGAAATGATAAAATTAGCCAGCTTACCAGGATGGGAC
Downstream sequence
ATTTTGTCCATTTTGTGGCTAGATTTAGGGAACCTGAGTGTCTGATACAAACTTTCCGACATGGTCAAAAAAGCCTTCCTTTTATCTGTCTTGAAAATCT
Reference
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.