Basic Information
VIS ID
TVIS10017830
Fusion event
HBV-KIAA0825 integration
Validated
No
Detection method
TS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26867494
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
DQ089769.1
Region type
core protein;X protein;
Start
1825
Integrated sequence
AAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTGGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTT| |CACCTCTGCCTAATCATCTCATGTTCATGTCCCACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAAT
Host Sequence
Chromosome
chr5
Cytoband
q15
Reference genome
GRCh37/hg19
Start
93642351/94306646 (Hg38)
End
93642351/94306646 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA5B
Target gene
KIAA0825
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-10397/Upstream/685858; hsa-mir-103a-1/Downstream/1772492;
Nearest TSS
ENST00000502646/Upstream/194947; ENST00000508383/Downstream/170538;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/194915, chr5-CpG: 77/Downstream/311562
Upstream sequence
GGACCGACCGCGAGCGGAGGCGCTGGGCGTCGGGAAGTGCGCACCCAAGTCCGGGGCCCGGCCGGGATGGATCTCCGGCGCGCGTGGGTCGGGACGGCGC
Downstream sequence
AATAATATTTAAGGGATTATTTTGAGGAAAATATAGAGATATTAGAGGGAAATTATCAAAGATATCATTAACAATACTGATTGATAACAATACCGAGCAA
Reference
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.
Curate