Basic Information
VIS ID
TVIS10017831
Fusion event
HBV-NREP integration
Validated
No
Detection method
TS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26867494
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
DQ089769.1
Region type
pre-S1/pre-S2/S;Polymerase;
Start
3197
Integrated sequence
TATTGACAACAGTACCAGCAGCGCCTCCTCCTGCCTCCACCAATCGGCAGTCAGGAAGACAGCCTACTCCCATCTCTCCACCTCTAAGAGACAGTCATCC| |TCAGGCCATGCAGTGGAA
Host Sequence
Chromosome
chr5
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
111163096/111827399 (Hg38)
End
111163096/111827399 (Hg38)
Location type
Intronic
Target gene
NREP
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-98-5p ; hsa-mir-29b-3p ; hsa-mir-4752 ; hsa-mir-6833-5p ; hsa-mir-3613-5p ; hsa-mir-3190-3p ; hsa-mir-6077 ; hsa-mir-571 ; hsa-mir-219a-1-3p ; hsa-mir-641 ; hsa-mir-3617-5p ; hsa-mir-7-5p
Nearest miRNA
hsa-mir-10397/Upstream/1313484; hsa-mir-103a-1/Downstream/4428344;
Nearest TSS
ENST00000502646/Upstream/69181; ENST00000508389/Downstream/85109;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/69182, chr5-CpG: 51/Downstream/333311
Upstream sequence
CCAGCTGTGATTTCCAGGTGGTCTCAGAGGAGTGTCCTGTGCAGCCCGGCCCTAAAATTCCAGCGTTAGGCTCCTCCGGGGCTTCCCAGAATGGCCTTGC
Downstream sequence
CAAGGATCACTGGCAGAGTCAAAGATTTTTACAAAATGGCTACACAATGCCCAAGTTACTGAGGAACCAGGCTGCTCCTCCAAGGTTATGAGGTCATCCA
Reference
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.
Curate