Basic Information
VIS ID
TVIS10017832
Fusion event
HBV-ASZ1 integration
Validated
No
Detection method
TS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26867494
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
DQ089769.1
Region type
X protein;
Start
1794
Integrated sequence
CTTGAGGCATACTTCAAAGACTGTGTATTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTGGGAGGCTGTAGGCATAAAT| |TGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCCACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTT
Host Sequence
Chromosome
chr7
Cytoband
q31.2
Reference genome
GRCh37/hg19
Start
117065057/117425003 (Hg38)
End
117065057/117425003 (Hg38)
Location type
Intronic
Target gene
ASZ1
miRNAs that regulate target gene
hsa-mir-221-3p
Nearest miRNA
hsa-mir-10525/Upstream/404684; hsa-mir-10399/Downstream/9633085;
Nearest TSS
ENST00000635602/Upstream/101714; ENST00000546407/Downstream/2495;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/100368, chr7-CpG: 33/Downstream/2346
Upstream sequence
ccactttgtcaatttctgcaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaggcagctcctcagctgtcattttgatagggattgccctgagtctgagaatc
Downstream sequence
gatttggtaacttagtcaaggttacaaagccatcaagtggcatggttagtaatcaaacccagatctgtcttgttttcaaaattatttacttttcagtaaa
Reference
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.
Curate