Basic Information
VIS ID
TVIS10017838
Fusion event
HBV-DNAAF4 integration
Validated
No
Detection method
TS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26867494
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
DQ089769.1
Region type
X protein;
Start
1719
Integrated sequence
GTGAACGCCCGACAGGTCTTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTG| |TATTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTGGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAA
Host Sequence
Chromosome
chr15
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
55765193/55472995 (Hg38)
End
55765193/55472995 (Hg38)
Location type
Intronic
Target gene
DNAAF4
Nearest miRNA
hsa-mir-10393/Upstream/99961; hsa-mir-11181/Downstream/3698188;
Nearest TSS
ENST00000557528/Upstream/55297; ENST00000561155/Downstream/25346;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/64387, chr15-CpG: 37/Downstream/25108
Upstream sequence
cggcttcccaaagtgctgggattagaggcatgagccactgcgcccggccCTGTCTACTTTTAATAGTGGAAAACTATTATTTTTAAAGCCTCAAAGACTA
Downstream sequence
tctctactaaaaatacaaaaattagctaggtgtggtagcgcacacctgtaatcccagctattcgggaggctgaggcatgagaatcgcttaaacccaagag
Reference
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.
Curate