IQCA1 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017851
Fusion event
HBV-IQCA1 integration
Validated
No
Detection method
TS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26867494
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
DQ089769.1
Region type
core protein;X protein;
Start
1826
Integrated sequence
AGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTGGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCATGTTCATGTCCCACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATT
Host Sequence
Chromosome
chr2
Cytoband
q37.3
Reference genome
GRCh37/hg19
Start
237328256/236419613 (Hg38)
End
237328256/236419613 (Hg38)
Location type
Intronic
Target gene
IQCA1
miRNAs that regulate target gene
hsa-mir-193b-3p
Nearest miRNA
hsa-mir-10b/Upstream/3869040; hsa-mir-149/Downstream/1091318;
Nearest TSS
ENST00000437798/Upstream/6722; ENST00000447924/Downstream/35498;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/181680, chr2-CpG: 33/Downstream/87834
Upstream sequence
GTTTTCATCAAGAATGAATCTACTACCTAAGAAGGAAACAACATTCCAAAGGCCATATGAGATGATGTAAAACAAACACATTTCTAAATGGGGGTAGAAT
Downstream sequence
GTGCCAGCCCTGCCCACAGCTCGTCAAAATCCAGGGGGAGGATGCCACTGCTTCCTGCTAGGCTCCAATGGCAACAGCCACTCTTGCAATAACTTTCATT
Reference
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.
Curate