Fusion event
HBV-SRPX2 integration
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Region type
pre-S1/pre-S2/S;Polymerase;
Integrated sequence
TCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTACCAAGGT| |ATGTTGCCCGTTTGTCCTCTACTTCCAGGAACATCAACTACCAGCACGGGACCATGCAAGACCTGCACGATTCCTGCTCAAGGAACCTCTATGTTTCCCT
End
99905827/100650830 (Hg38)
miRNAs that regulate target gene
Nearest miRNA
hsa-let-7f-2/Upstream/5587604; hsa-mir-105-1/Downstream/5988984;
Upstream sequence
TTACTGTCCCATGAAGTTATTTAACCAGCGTGTTTATGTATGCTAGAATGGTACCAAGCTGTTGCTGACAAATGATCCATTGGAAGCAGCGCATGGAGGC
Downstream sequence
GGAGGTCCCACAGGCTCCTGCCCTGGACTACCGAGGTAATCTACCCTGCTTCTCAAGCCCAGAAAATCTCTTTTCTGGCCTCAGACCTAGGCCCTTCCCT
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.