VISDB - VIS Detail

Expression analysis of TCGA samples

Basic Information

VIS ID

TVIS10017864

Fusion event

HBV-PI4KB integration

Validated

No

Detection method

TS

Data source

Curated

Sample type

Tumor

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

26867494

Virus Sequence

Virus name

HBV

Subtype

C

Reference genome

DQ089769.1

Region type

pre-S1/pre-S2/S;Polymerase;

Start

3173

Integrated sequence

GGTGGAGCCCTCAGGCTCAGGGCATATTGACAACAGTACCAGCAGCGCCTCCTCCTGCCTCCACCAATCGGCAGTCAGGAAGACAGCCTACTCCCATCTC| |TCCACCTCTAAGAGACAGTCATCCTCAGGCCATGCAGTGGAA

Host Sequence

Chromosome

chr1

Cytoband

q21.3

Reference genome

GRCh37/hg19

Start

151265228/151292752 (Hg38)

End

151265228/151292752 (Hg38)

Location type

3UTR

Fragile sites / regions

FRA1F

Target gene

PI4KB

miRNAs that regulate target gene

hsa-mir-191-5p ; hsa-mir-877-3p ; hsa-mir-331-3p ; hsa-mir-23b-3p ; hsa-mir-18a-5p

Nearest miRNA

hsa-mir-101-1/Upstream/740738; hsa-mir-1182/Downstream/253044;

Nearest TSS

ENST00000473358/Upstream/2301; ENST00000609583/Downstream/1721;

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/9459, chr1-CpG: 21/Downstream/35294

Upstream sequence

ACACACCTTTGCCTTATTAAAAGTCAAACAGAAATAAACAACACAGTCCATGTGTGTCATAGAAAGGGATTTCAAATAGGCCCAAAGTCAATCCTACCTC

Downstream sequence

TGATATTCAGAGCTTCAGACTTTTTCTCTTTTTTCATCATGTCTTCTGGCTCATTCTGGGTGTTGAAGGAATCACCTGCATTCAAAGAAGAAACCTTGTG

Reference

Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.