LXN _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017880
Fusion event
HBV-LXN integration
Validated
No
Detection method
TS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26867494
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
DQ089769.1
Region type
core protein;Polymerase;
Start
2449
Integrated sequence
ACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGT| |TAGTATCCCTTGGACTCATAAGGTGGGAAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTGACTGGCAAACTCCCTCTTTTCCTCAC
Host Sequence
Chromosome
chr3
Cytoband
q25.32
Reference genome
GRCh37/hg19
Start
158390213/158672424 (Hg38)
End
158390213/158672424 (Hg38)
Location type
Exonic
Fragile sites / regions
FRA3D
Target gene
LXN
miRNAs that regulate target gene
hsa-mir-92a-3p
Nearest miRNA
hsa-let-7g/Upstream/7106429; hsa-mir-1224/Downstream/610222;
Nearest TSS
ENST00000440867/Upstream/2831; ENST00000481468/Downstream/269;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/27735, chr3-CpG: 91/Downstream/59582
Nearest cancer related gene
LXN(TSG, No orient, 0)
Upstream sequence
AAGGTAAGTCCTATATTTACCATAGAAGTTTCAAGTTTATTAGAGCAAATCATAATCTAGAAACAATAGTGAACATGAATGATATTACAAAAGTGTTTCC
Downstream sequence
CTGTGCCACCAAGGCCGCCCTGGAGGCTGGGTAGTTGGTCGGCGGGATTTCCATTCCGGATGAGCAGTGACTTCAGGGCTTGGGCTACTCTGGCTTAACG
Reference
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.
Curate