Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene3400181933523535338921923373559333737402337194453372086133725355337266793373471633734865337613363376144533762677
ADAMTS12 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017883
Fusion event
HBV-ADAMTS12 integration
Validated
No
Detection method
TS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26867494
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
DQ089769.1
Region type
X protein;
Start
1812
Integrated sequence
GACTGTGTATTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTGGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCAC| |CATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCCACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGAC
Host Sequence
Chromosome
chr5
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
33762782/33762677 (Hg38)
End
33762782/33762677 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA5A
Target gene
ADAMTS12
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-26b-5p
Nearest miRNA
hsa-mir-10397/Upstream/1368202; hsa-mir-103a-1/Downstream/2385215;
Nearest TSS
ENST00000502646/Upstream/138326; ENST00000330120/Downstream/77635;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/260419, chr5-CpG: 25/Downstream/129409
Upstream sequence
TGGCCGGGGCCAGGGCTTCCCACGTGCGCAGCAGGACGCAGCGCTGCCTGAAACTCGCGCCGCGAGGAGAgggcggggccgcggaaaggaaggggagggg
Downstream sequence
GAAGAAAATGGGGATTCTTCCCTGGAGCATGATAGGAAATGTACAACATAATCTACTTTACCATTTTTACCTATGACATCTTCAGTAAACTATTCATTGT
Reference
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.
Curate