Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017893
Fusion event
HBV-MOB2 integration
Validated
No
Detection method
TS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
Region type
X protein;
Start
1800
Integrated sequence
GCATACTTCAAAGACTGTGTATTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTGGGAGGCTGTAGGCATAAATTGGTCT| |GTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCCACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGC
Host Sequence
Chromosome
chr11
Cytoband
p15.5
Reference genome
Start
End
1679742/1658512 (Hg38)
Location type
Intronic
Target gene
Nearest miRNA
hsa-mir-210/Upstream/401842; hsa-let-7a-2/Downstream/200952;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/5518, chr11-CpG: 21/Downstream/35605
Upstream sequence
acacacagatctgggttcaaatcccagctctaccaattactcagacctgtgaccttgagcaagtATTTGCCTCACATAAAGTATGCAGGATGCCCTTACC
Downstream sequence
TCCTCCGGCAAACTGCAGGAGGACGTGGCAGCCAGCTCTGACACCTGTTAGGTCTTTACTGCAGGAACACGTTCTTTGTCCCTTTCCAACTGTAGCCCTG
Reference
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.