Basic Information
VIS ID
TVIS10017894
Fusion event
HBV-DEUP1 integration
Validated
No
Detection method
TS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26867494
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
DQ089769.1
Region type
X protein;
Start
1753
Integrated sequence
ATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTGTATTTAAAGACTGGGAGGAGTTGGGGGAGGAGAT| |TAGATTAAAGGTCTTTGTACTGGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCAT
Host Sequence
Chromosome
chr11
Cytoband
q21
Reference genome
GRCh37/hg19
Start
93117111/93383945 (Hg38)
End
93117111/93383945 (Hg38)
Location type
Intronic
Target gene
DEUP1
Nearest miRNA
hsa-mir-10392/Upstream/2514743; hsa-let-7a-2/Downstream/349729;
Nearest TSS
ENST00000527297/Upstream/477; ENST00000529909/Downstream/27114;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/53035, chr11-CpG: 116/Downstream/158703
Nearest cancer related gene
DEUP1(TSG, No orient, 0)
Upstream sequence
AAACCTAAGCAGATTTTTAATAACTCATATTCGAGGGCTATTATAGCATATTTTTACTTTAACAAGTAGGTAAGAGAAAATGCAATTTGAACATAAAGAT
Downstream sequence
TCTTAAAAGCTAAGCCCAGGTGCAAATGACCATGAAGGAGGATGGCTTATCACCGATGAAAAACTGGTTGCAAGTTAACATAGATAATCTGAGTCTAAAT
Reference
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.
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