Fusion event
HBV-CLMN integration
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Region type
X protein;Polymerase;
Integrated sequence
AATCCCGCGGACGACCCGTCTCGGGGCCGTTTGGGACTCTACCGTCCCCTTCTTCGTCTGCCGTTCCGGCCGACCACGGGGCGCACCTCTCTTTACGCGG| |TCTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCGACAGGTCTTGCCC
End
95659974/95193637 (Hg38)
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-1260a/Upstream/55651; hsa-mir-1185-1/Downstream/4915782;
Upstream sequence
aagcttgccctgtaaggagtgtctggtgaagggaaggtaaagattataattgcatttctaaggaactaagtgggaagtgggagaaaggagaaaaggagaa
Downstream sequence
ACCATCAGTGTTAATTAATATCTACTTTTCCTTTCTACTCATATTCAATTTACATCATTTTCTCTGGAATAGTTATTTTCTTGCATTATCCCAAATTATT
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.