VISDB Viral Integration Site DataBase

VIS ID

TVIS10017911

Fusion event

HBV-FHIT integration

Validated

No

Detection method

TS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

Virus name

HBV

Subtype

C

Reference genome

Region type

X protein;

Start

1801

Integrated sequence

CATACTTCAAAGACTGTGTATTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTGGGAGGCTGTAGGCATAAATTGGTCTG| |TTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCCACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCA

Chromosome

chr3

Cytoband

p14.2

Reference genome

Start

End

59853271/59867545 (Hg38)

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-143-3p ; hsa-mir-217 ; hsa-mir-331-3p ; hsa-mir-625-5p

Nearest miRNA

hsa-let-7g/Upstream/4014951; hsa-mir-12124/Downstream/750260;

Nearest TSS

Nearest CpG islands

None/Target, chr3-CpG: 148/Upstream/817327, chr3-CpG: 48/Downstream/1383387

Nearest cancer related gene

FHIT(TSG, No orient, 0)

Upstream sequence

cacttgcacttgggaggcggaggtttcagtgagccaagattgcgccactgaactgcagtctgggtgacacagggagactgtgtctcagaaacaaacaaaa

Downstream sequence

TTTATGCATTTTGCTTTATTTTGTGATTACTTTATCTCACTATCCTCCCCTTTTTCTGCTTGTGTGATTGCCTTAATCCTTTTATCTAGAACCAGGGGGA