VISDB Viral Integration Site DataBase

VIS ID

TVIS10017919

Fusion event

HBV-POLE3 integration

Validated

No

Detection method

TS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

Virus name

HBV

Subtype

C

Reference genome

Region type

core protein;X protein;

Start

1823

Integrated sequence

TAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTGGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTT| |TTCACCTCTGCCTAATCATCTCATGTTCATGTCCCACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGA

Chromosome

chr9

Cytoband

q32

Reference genome

Start

End

116169880/113407600 (Hg38)

Location type

3UTR

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-155-5p ; hsa-mir-7-5p ; hsa-mir-26b-5p ; hsa-mir-18a-3p ; hsa-mir-153-3p ; hsa-mir-4709-3p ; hsa-mir-219a-2-3p ; hsa-mir-219b-3p ; hsa-mir-3185 ; hsa-mir-3145-3p ; hsa-mir-4756-3p ; hsa-mir-6768-3p ; hsa-mir-4753-5p ; hsa-mir-1200 ; hsa-mir-1276 ; hsa-mir-1321 ; hsa-mir-145-3p ; hsa-mir-2392 ; hsa-mir-2909 ; hsa-mir-299-5p ; hsa-mir-3162-5p ; hsa-mir-3605-5p ; hsa-mir-376a-5p ; hsa-mir-378a-5p ; hsa-mir-4311 ; hsa-mir-4324 ; hsa-mir-4739 ; hsa-mir-4756-5p ; hsa-mir-4760-5p ; hsa-mir-5192 ; hsa-mir-544b ; hsa-mir-583 ; hsa-mir-6731-5p ; hsa-mir-6760-5p ; hsa-mir-8061 ; hsa-mir-8069 ; hsa-mir-8085

Nearest miRNA

hsa-let-7a-1/Upstream/1475431; hsa-mir-12126/Downstream/801834;

Nearest TSS

Nearest CpG islands

None/Target, chr9-CpG: 64/Upstream/6032, chr9-CpG: 78/Downstream/2423

Upstream sequence

GAGCCGCCCTGTGCCTCATGCGGCGACCGAGGCGCCCTCGGGAGACGGGCCCTGTCGGGTGTCGAGACGCGAACACGACCCAATGCCAAGAACGGGCGGT

Downstream sequence

CCGCCTCCGGCAAAGCCCCGTCGGCCGCCGCCATCTCTGGCCCACTCCGAGGACCTAGCTCCCAGCTCCACGCACGCGCACTGCACGCCGAGGCGAGCCA