VISDB Viral Integration Site DataBase

VIS ID

TVIS10017920

Fusion event

HBV-PRKAB2 integration

Validated

No

Detection method

TS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

Virus name

HBV

Subtype

C

Reference genome

Region type

X protein;

Start

1773

Integrated sequence

TCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTGTATTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTAC| |TGGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCCACTGTTCAAGCCTCC

Chromosome

chr1

Cytoband

q21.1

Reference genome

Start

End

146644586/147173007 (Hg38)

Location type

upstream

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-29c-3p ; hsa-mir-103a-3p ; hsa-mir-21-5p ; hsa-mir-16-5p ; hsa-mir-615-3p ; hsa-mir-186-5p ; hsa-mir-30c-5p ; hsa-mir-3921 ; hsa-mir-4653-5p ; hsa-mir-580-3p ; hsa-mir-5687 ; hsa-mir-6761-5p ; hsa-mir-4329 ; hsa-mir-4251 ; hsa-mir-301b-5p ; hsa-mir-301a-5p ; hsa-mir-146a-3p ; hsa-mir-3668 ; hsa-mir-5680 ; hsa-mir-216b-5p ; hsa-mir-450a-1-3p ; hsa-mir-519e-5p ; hsa-mir-515-5p ; hsa-mir-597-3p ; hsa-mir-8059 ; hsa-mir-4471 ; hsa-mir-1292-5p ; hsa-mir-4803

Nearest miRNA

hsa-mir-101-1/Upstream/1322362; hsa-mir-1182/Downstream/1161472;

Nearest TSS

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/85, chr1-CpG: 34/Downstream/5036

Nearby gene

PRKAB2(+) ;

Upstream sequence

gcttggaaatccagcagcaagaagatgtctcactcccaaagtccataactcaatccttgggaagactgtagttggtcctgctaggaacacgtaactatcc

Downstream sequence

AACTATCCTCCAGATAGGGAGCTGGGGAGATGGGAGATGGGCTCCTCTGACAGGACACCCTGTGGTTCACGTCCACTCTTGTGGCCTGGGTATATTGGGA