VISDB Viral Integration Site DataBase

VIS ID

TVIS10017921

Fusion event

HBV-COPA integration

Validated

No

Detection method

TS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

Virus name

HBV

Subtype

C

Reference genome

Region type

X protein;Polymerase;

Start

1528

Integrated sequence

GTCCCGTCGGCGCTGAATCCCGCGGACGACCCGTCTCGGGGCCGTTTGGGACTCTACCGTCCCCTTCTTCGTCTGCCGTTCCGGCCGACCACGGGGCGCA| |CCTCTCTTTACGCGGTCTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCC

Chromosome

chr1

Cytoband

q23.2

Reference genome

Start

End

160264286/160294496 (Hg38)

Location type

Exonic

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-744-5p ; hsa-mir-421 ; hsa-mir-92b-3p ; hsa-mir-193b-3p ; hsa-mir-423-3p ; hsa-mir-23b-3p ; hsa-mir-10a-5p ; hsa-mir-1260b ; hsa-mir-127-5p ; hsa-mir-3591-5p ; hsa-mir-376b-3p ; hsa-mir-376a-3p ; hsa-mir-7153-5p ; hsa-mir-142-3p ; hsa-mir-146b-5p ; hsa-mir-146a-5p ; hsa-mir-589-5p ; hsa-mir-539-5p ; hsa-mir-4712-3p ; hsa-mir-3976 ; hsa-mir-648 ; hsa-mir-4517 ; hsa-mir-3652 ; hsa-mir-4430 ; hsa-mir-4634 ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-4746-3p ; hsa-mir-4695-3p

Nearest miRNA

hsa-mir-101-1/Upstream/394417; hsa-mir-1182/Downstream/932690;

Nearest TSS

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/31835, chr1-CpG: 38/Downstream/48642

Upstream sequence

taaaagactacacagaaaactattagaactgttaagcaaattcagtaaagtcgcaggatacaaaatcaacatacaaaaatcagtagcatttctatatgcc

Downstream sequence

aacagttaaaaatctaaaaaagaaatcaaaaagcaattccatttacaatagtcacaaatataattcaatacataggaattaatgtaaccaaagaagtgaa