Basic Information
VIS ID
TVIS10017939
Fusion event
HBV-ATP5ME integration
Validated
No
Detection method
TS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26867494
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
DQ089769.1
Region type
pre-S1/pre-S2/S;Polymerase;
Start
398
Integrated sequence
CCTGGCCAAAATTTGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAATTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCA| |TCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTACCAAGGTATGTTGCCCGTTTGTCCTCTACTTCCAGGAACATCAAC
Host Sequence
Chromosome
chr4
Cytoband
p16.3
Reference genome
GRCh37/hg19
Start
666304/672515 (Hg38)
End
666304/672515 (Hg38)
Location type
Exonic
Target gene
ATP5ME
miRNAs that regulate target gene
hsa-mir-877-3p
Nearest miRNA
hsa-mir-571/Upstream/322263; hsa-mir-12113/Downstream/1313869;
Nearest TSS
ENST00000502981/Upstream/7605; ENST00000502720/Downstream/1008;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/8142, chr4-CpG: 123/Downstream/969
Upstream sequence
ATAAATATTGTCATAGCCTCAACACCAAGACATAACCACATTTTGGAAATATATCTTGTAAAAAGCCAAAGGGGAAAGGGTGGTAGGAAATGAATACATA
Downstream sequence
TCATCTTGGGCCGGAAGGTTAGAAGAAAAGCACATGTTACCACTCAGGCAACCTAAAAAGACCACTTCAGCTTCCCAGttattttttttttttttttttt
Reference
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.
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