Basic Information
VIS ID
TVIS10018273
Fusion event
HBV-chr2 integration
Validated
No
Detection method
RNA-Seq
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2017
PubMed ID
28622513
Virus Sequence
Virus name
HBV
Reference genome
Not given
Start
1806
Host Sequence
Chromosome
chr2
Cytoband
p16.1
Reference genome
GRCh37/hg19
Start
58359726/58132591 (Hg38)
End
58385250/58158115 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
FANCL ; VRK2
miRNAs that regulate target gene
hsa-mir-30e-5p ; hsa-mir-30c-5p ; hsa-mir-30d-5p ; hsa-mir-30b-5p ; hsa-mir-30a-5p
Nearest miRNA
hsa-mir-1301/Upstream/2131796; hsa-mir-10b/Downstream/2229247;
Nearest TSS
ENST00000437798/Upstream/85716; ENST00000608934/Downstream/7688;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/85304, chr2-CpG: 50/Downstream/82863
Upstream sequence
ACTTTACAATAGATCTTTGGAATTAACCGAAAACTTTACATTTAACAGCATAAACGTATTTACTGTACATCAAGTACACATTTCCTTGAATTCCAATTTT
Downstream sequence
CCTAAGTGGAGATATCTCCCAGCCTTGCACATGTGAGCTATATGTAAATGCTGCTCTATGATTTGATAGCATAATTATTATTTGTATTATGCTTTATAGG
Target sequence
AGAATAGCCAGTTTTTCATTATATACCAAGATATGCTCAACAGTAGTTATCCACAGGTAGCAAAAGCAGCAGCTAAGCTAAGTTTTAAGTAGGAAAATCACAACAGAAGAGTACAAAGCCAGGGGAAAATTAGCTGATTCATAGAAATCTATCTTTAAATTCAGTGTGGCATCAGTTCTTAATACTGAGAAAGATTAGCCTGCAGATTCAGAAAAATACATATTACATTTGTAAATACTGACATATATGAAACAT
Reference
Cancer Genome Atlas Research Network. Electronic address, w. b. e. and N. Cancer Genome Atlas Research . Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma. Cell ,2017,169(7): 1327-1341 e13
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