VISDB Viral Integration Site DataBase

VIS ID

TVIS10018418

Fusion event

HBV-CLU integration

Validated

No

Detection method

VirusFinder

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2017

PubMed ID

Virus name

HBV

Reference genome

Start

442

End

1705

Integrated sequence

TTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTC

Chromosome

chr8

Cytoband

p21.1

Reference genome

Start

End

27464042/27606525 (Hg38)

Location type

Exon6

Target gene

miRNAs that regulate target gene

hsa-mir-425-5p ; hsa-mir-18a-3p ; hsa-mir-17-5p ; hsa-mir-21-5p ; hsa-mir-1228-5p ; hsa-mir-1237-5p ; hsa-mir-1254 ; hsa-mir-1275 ; hsa-mir-1286 ; hsa-mir-15a-5p ; hsa-mir-15b-5p ; hsa-mir-16-5p ; hsa-mir-195-5p ; hsa-mir-2467-3p ; hsa-mir-25-5p ; hsa-mir-2861 ; hsa-mir-3116 ; hsa-mir-3152-3p ; hsa-mir-3175 ; hsa-mir-3191-5p ; hsa-mir-326 ; hsa-mir-330-5p ; hsa-mir-3612 ; hsa-mir-3659 ; hsa-mir-3678-3p ; hsa-mir-424-5p ; hsa-mir-4254 ; hsa-mir-4259 ; hsa-mir-4443 ; hsa-mir-4486 ; hsa-mir-4488 ; hsa-mir-4505 ; hsa-mir-4661-3p ; hsa-mir-4665-5p ; hsa-mir-4697-5p ; hsa-mir-4706 ; hsa-mir-4722-5p ; hsa-mir-4731-5p ; hsa-mir-4749-5p ; hsa-mir-4781-5p ; hsa-mir-485-5p ; hsa-mir-497-5p ; hsa-mir-518c-5p ; hsa-mir-520a-5p ; hsa-mir-525-5p ; hsa-mir-5586-3p ; hsa-mir-571 ; hsa-mir-5787 ; hsa-mir-650 ; hsa-mir-6731-5p ; hsa-mir-6751-5p ; hsa-mir-6764-3p ; hsa-mir-6777-5p ; hsa-mir-6803-5p ; hsa-mir-6817-3p ; hsa-mir-6824-3p ; hsa-mir-6838-5p ; hsa-mir-6846-5p ; hsa-mir-6848-5p ; hsa-mir-6873-3p ; hsa-mir-6884-5p ; hsa-mir-6889-5p ; hsa-mir-7109-5p ; hsa-mir-7110-3p ; hsa-mir-7855-5p ; hsa-mir-8085 ; hsa-mir-873-5p ; hsa-mir-890 ; hsa-mir-922

Nearest miRNA

hsa-mir-124-1/Upstream/172919; hsa-mir-10400/Downstream/4076;

Nearest TSS

Nearest CpG islands

None/Target, chr8-CpG: 109/Upstream/13807, chr8-CpG: 46/Downstream/7912

Nearest cancer related gene

CLU(TSG, No orient, 0)

Upstream sequence

TTAATACATTTTAGTTATTTTTCTTTCTTCATGTGAGTGTAGTAAAAGAAGCAGGAAAAATAATCTAATACGTATCTATTAAACAAAAATGTTTTTCTGC

Downstream sequence

TACAGGAAGACACAAGGCTGGCTGAGCCACACAGAGACCACAGGCTCATGCACTCAAAGAGCTGCTGGGTGCCAGGCCCTCTGCCCCAGGGCAGGCCTTC

Target sequence

CTGGCGGCCAACCAGGCCTGAGCCACTTCTGCAGACGCGTGCGTAGAACTTCATGCAGGTCTGTTTCAGGCAGGGCTTACACTCTTCCCAGAGGGCCATCATGGTCTCATTGCACACTCCTGGGAGCTCCTTCAGCTTTGTCTCTGATTCCCTGGTCTCATTTAGGGCATCC