Basic Information
VIS ID
TVIS10018426
Fusion event
HBV-chr18 integration
Validated
No
Detection method
VirusFinder
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2017
PubMed ID
29212479
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1507
End
1887
Integrated sequence
GTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTA
Host Sequence
Chromosome
chr18
Cytoband
q12.1
Reference genome
GRCh37.55
Start
26408018/28828054 (Hg38)
End
26408282/28828317 (Hg38)
Nearest miRNA
hsa-mir-1-2/Upstream/2236519; hsa-mir-122/Downstream/1470593;
Nearest TSS
ENST00000575820/Upstream/42986; ENST00000584482/Downstream/533646;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/649843, chr18-CpG: 128/Downstream/2213206
Nearby gene
CDH2
Upstream sequence
AAATGTTGGGGTTGGGGGAGAGGGCAGGAATTGACCTTAAATGAACACACTCTATGTTaatgatcctatgctaggtacattattcctagcaatttctaaa
Downstream sequence
CTTTTCCTTGCCATCTGCTCACCCACACTGCTGATTTTTCCTACCAGCAGGTGTCAAGTTTCTTCAATCTGTTCAACTCTGATATTCTTCAACTCTGGca
Target sequence
caaggaaattgaggctcagTGTTTGTGACATTTGAATTCACTAAGTGCACCACAGATGAATAGACAAGTCTGTTAAATTCTAAAATCTAAATTTTATCATAGTTACTTATTCCTTTACAATAAGTTAGAGTTTTAAAATATTGCATACTTGCTCTTTTTAAATCAGTTGTTACACTTGCAAAACCACTTTCTTAATACTATAATTTATTCATGTCTTAAAGTTTGTCTGTCCATCCAATTGCTTTGCTCACTGCT
Reference
Yoo, S., et al. A pilot systematic genomic comparison of recurrence risks of hepatitis B virus-associated hepatocellular carcinoma with low- and high-degree liver fibrosis. BMC Med ,2017, 15(1): 214.
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