Basic Information
VIS ID
TVIS10018432
Fusion event
HBV-chr11 integration
Validated
No
Detection method
VirusFinder
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2017
PubMed ID
29212479
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
548
End
1616
Integrated sequence
CTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAGCATCTTGAGTCCCTTTTTACCGCTGTT
Host Sequence
Chromosome
chr11
Cytoband
p15.5
Reference genome
GRCh37.55
Start
2152799/2131569 (Hg38)
End
2153026/2131796 (Hg38)
Location type
Exon
Target gene
IGF2 ; INS-IGF2
miRNAs that regulate target gene
hsa-let-7a-5p ; hsa-mir-125b-5p ; hsa-mir-150-5p ; hsa-mir-615-5p ; hsa-mir-877-5p ; hsa-mir-93-5p ; hsa-mir-100-5p ; hsa-mir-9-3p ; hsa-mir-6881-5p ; hsa-mir-6738-5p ; hsa-mir-5194 ; hsa-mir-1914-3p ; hsa-mir-339-3p ; hsa-mir-4521 ; hsa-mir-6891-5p ; hsa-mir-4779 ; hsa-mir-3173-3p ; hsa-mir-4428 ; hsa-mir-4429 ; hsa-mir-320d ; hsa-mir-320c ; hsa-mir-320b ; hsa-mir-320a ; hsa-mir-5003-3p ; hsa-mir-4662a-5p ; hsa-mir-429 ; hsa-mir-200c-3p ; hsa-mir-8084 ; hsa-mir-200b-3p ; hsa-mir-4728-3p ; hsa-mir-3622a-3p ; hsa-mir-6763-3p ; hsa-mir-6802-3p ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-6862-3p ; hsa-mir-6784-3p ; hsa-mir-6078 ; hsa-mir-1915-5p ; hsa-mir-4485-5p ; hsa-mir-3162-3p ; hsa-mir-5587-3p ; hsa-mir-4707-5p ; hsa-mir-1224-3p ; hsa-mir-3200-3p ; hsa-mir-663b
Nearest miRNA
hsa-mir-210/Upstream/134738; hsa-let-7a-2/Downstream/2338;
Nearest TSS
ENST00000527297/Upstream/140473; ENST00000381363/Downstream/5491;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/118808, chr11-CpG: 23/Downstream/1007
Nearest cancer related gene
IGF2(OG, No orient, 0)
Upstream sequence
CCACACGTGAAAAACAAACCCAACTAAATTTCAGTAAAATTACAGAATATTTGAAGAAATTAATCTTTTCACTAACTTCATTTTGTATACATGTATACAA
Downstream sequence
gtgtgctgtgtgtgcatgtgtgtgcgtgtgctgtgcgtttgtgtgctgtgtgctcgtgtgtgtgctgtgtgtgcgtgtgtgctgtgcgtttgtgtgtgct
Target sequence
tgtgtgtgctgtgttcatgtgtgctgtgcatgcgtgtgtgctgtgtgtgcatgtgtgtgctgtgtgctgtgttcatgtgtgtgctgtgtgtgcgtgtgctgtgtgcatgtgtgtgctgtgtttgtgtgtgtgctgtgtgtgctgtgttcgtgtgtgctgtgttcgcgtgtgtgtgctgtgtgtgcatgtgtgtgctgtgtctttgtgtgtgtgctgtgtgctagtgt
Reference
Yoo, S., et al. A pilot systematic genomic comparison of recurrence risks of hepatitis B virus-associated hepatocellular carcinoma with low- and high-degree liver fibrosis. BMC Med ,2017, 15(1): 214.
Curate