Basic Information
VIS ID
TVIS10018445
Fusion event
HBV-chr9 integration
Validated
No
Detection method
VirusFinder
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29212479
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1703
Integrated sequence
CGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGG| |CATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTG
Host Sequence
Chromosome
chr9
Cytoband
p24.1
Reference genome
GRCh37.55
Start
5864103/5864103 (Hg38)
End
5864103/5864103 (Hg38)
Location type
Intronic
Target gene
ERMP1 ; KIAA2026
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-335-5p ; hsa-mir-125a-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-let-7a-5p ; hsa-mir-218-5p ; hsa-mir-4693-5p ; hsa-mir-223-5p ; hsa-mir-4720-3p ; hsa-mir-4804-3p ; hsa-mir-892a ; hsa-mir-4318 ; hsa-mir-4797-5p ; hsa-mir-429 ; hsa-mir-200c-3p ; hsa-mir-200b-3p ; hsa-mir-8485 ; hsa-mir-323a-3p
Nearest miRNA
hsa-mir-101-2/Upstream/1013728; hsa-let-7a-1/Downstream/143723;
Nearest TSS
ENST00000422679/Upstream/30986; ENST00000490518/Downstream/26699;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/30842, chr9-CpG: 135/Downstream/142861
Nearby gene
MLANA
Upstream sequence
ATATTGGGAATGAATTCCTGGGACAAACGGAGGAGCTTTCATCTCCTGAAGAAAAATGAAAAGCTACTTAGAGAACTTAGGAACTTGGATTCAAGGCAGT
Downstream sequence
ctcaaaataatcatgtattggactctcttatgattctggggttgactgggctcagcaaggcggttcatgcttggactctctcctgcaggtgcagtcagag
Reference
Yoo, S., et al. A pilot systematic genomic comparison of recurrence risks of hepatitis B virus-associated hepatocellular carcinoma with low- and high-degree liver fibrosis. BMC Med ,2017, 15(1): 214.
Curate