Basic Information
VIS ID
TVIS10018450
Fusion event
HBV-chr12 integration
Validated
No
Detection method
VirusFinder
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29212479
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1797
Integrated sequence
TTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATT| |GGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTT
Host Sequence
Chromosome
chr12
Cytoband
q24.11
Reference genome
GRCh37.55
Start
109490721/109052916 (Hg38)
End
109490721/109052916 (Hg38)
Location type
Intron
Fragile sites / regions
FRA12E
Target gene
USP30 ; USP30-AS1
miRNAs that regulate target gene
hsa-mir-877-5p ; hsa-mir-484
Nearest miRNA
hsa-let-7i/Upstream/215910; hsa-mir-1178/Downstream/780432;
Nearest TSS
ENST00000382841/Upstream/20; ENST00000467307/Downstream/1036;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/48, chr12-CpG: 26/Downstream/40386
Upstream sequence
CCAGGCTATTTAATGActttgcacatgcagttccttctgtctaaaattcacctttttcctttgtgagtctggcaaagaactactaagtagttaaacttca
Downstream sequence
TCGTATCAGTGAGAGAAAAATGAAGAAATACGGAGTTCTATTTTTTTTTATTACCTGTGTCTCTCTGATGAAATGTAAATCTTTTAAATGGCAAGTCGGG
Reference
Yoo, S., et al. A pilot systematic genomic comparison of recurrence risks of hepatitis B virus-associated hepatocellular carcinoma with low- and high-degree liver fibrosis. BMC Med ,2017, 15(1): 214.
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