VISDB Viral Integration Site DataBase

VIS ID

TVIS10018462

Fusion event

HBV-TOB2 integration

Validated

No

Detection method

VirusFinder

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2017

PubMed ID

Virus name

HBV

Reference genome

Start

1706

Integrated sequence

CGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCAT| |ACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGC

Chromosome

chr22

Cytoband

q13.2

Reference genome

Start

End

41840051/41444047 (Hg38)

Location type

Intron1

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-378a-3p ; hsa-mir-302a-3p ; hsa-mir-122-5p ; hsa-mir-877-5p ; hsa-mir-744-5p ; hsa-mir-106b-3p ; hsa-mir-320a ; hsa-mir-221-3p ; hsa-mir-630 ; hsa-mir-766-5p ; hsa-mir-3173-3p ; hsa-mir-6891-5p ; hsa-mir-4732-5p ; hsa-mir-3611 ; hsa-mir-7106-5p ; hsa-mir-765 ; hsa-mir-6081 ; hsa-mir-3202 ; hsa-mir-574-5p ; hsa-mir-7515 ; hsa-mir-1252-5p ; hsa-mir-6754-5p ; hsa-mir-4441 ; hsa-mir-4270 ; hsa-mir-4756-5p ; hsa-mir-4739 ; hsa-mir-1321 ; hsa-mir-4433b-3p ; hsa-mir-6876-5p ; hsa-mir-4476 ; hsa-mir-6510-5p ; hsa-mir-6838-5p ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p ; hsa-mir-7844-5p ; hsa-mir-4777-5p ; hsa-mir-526a ; hsa-mir-523-5p ; hsa-mir-522-5p ; hsa-mir-520c-5p ; hsa-mir-519c-5p ; hsa-mir-519b-5p ; hsa-mir-519a-5p ; hsa-mir-518f-5p ; hsa-mir-518e-5p ; hsa-mir-518d-5p ; hsa-mir-6770-5p ; hsa-mir-1253 ; hsa-mir-548ax ; hsa-mir-548ao-5p ; hsa-mir-8067 ; hsa-mir-5586-3p ; hsa-mir-6508-5p ; hsa-mir-6127 ; hsa-mir-5006-5p ; hsa-mir-6748-5p ; hsa-mir-6742-5p ; hsa-mir-92a-2-5p ; hsa-mir-4483 ; hsa-mir-6766-5p ; hsa-mir-1293 ; hsa-mir-6756-5p ; hsa-mir-6745 ; hsa-mir-363-5p ; hsa-mir-6747-5p ; hsa-mir-608 ; hsa-mir-4651 ; hsa-mir-4664-5p ; hsa-mir-342-5p ; hsa-mir-504-3p ; hsa-mir-4745-5p ; hsa-mir-4755-3p ; hsa-mir-4481 ; hsa-mir-6813-5p ; hsa-mir-6085 ; hsa-mir-3941 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-32-5p ; hsa-mir-92a-3p ; hsa-mir-92b-3p ; hsa-mir-1207-5p ; hsa-mir-125a-3p ; hsa-mir-3934-5p ; hsa-mir-4493 ; hsa-mir-4736 ; hsa-mir-4740-3p ; hsa-mir-4763-3p ; hsa-mir-506-5p ; hsa-mir-6815-5p ; hsa-mir-6865-5p ; hsa-mir-7150 ; hsa-mir-7160-3p ; hsa-mir-764 ; hsa-mir-892c-5p

Nearest miRNA

hsa-mir-1281/Upstream/190997; hsa-let-7a-3/Downstream/456897;

Nearest TSS

Nearest CpG islands

None/Target, chr22-CpG: 279/Upstream/29788, chr22-CpG: 177/Downstream/2206

Upstream sequence

TTCTGTTTCAAAGAGGAAAAGGAGGGATAATGGTGATGGAATCCACTGAGCCCCAAACCCAAAAAGATACTCAGACACCTCTAAGCCTTAAATGTGCAAA

Downstream sequence

CTGTCCTACAATGACGGACTACAGGACTCAACTAAGTGTGGAGGGGCCAGCAGGTGTCACAGACCGGGTGGATGCGAGTGCCCTGCCGCTGTCCGGGGAG