VISDB Viral Integration Site DataBase

VIS ID

TVIS10018486

Fusion event

HBV-TAGLN integration

Validated

No

Detection method

VirusFinder

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2017

PubMed ID

Virus name

HBV

Reference genome

Start

1498

End

1597

Integrated sequence

CCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCT

Chromosome

chr11

Cytoband

q23.3

Reference genome

Start

End

117074930/117204214 (Hg38)

Location type

Intron4

Fragile sites / regions

FRA11G ; FRA11B

Target gene

miRNAs that regulate target gene

hsa-mir-9-5p ; hsa-mir-128-3p ; hsa-mir-7-5p ; hsa-mir-26b-5p ; hsa-mir-6845-5p ; hsa-mir-6762-5p ; hsa-mir-486-3p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-6797-5p ; hsa-mir-1249-5p ; hsa-mir-423-5p ; hsa-mir-3184-5p ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-4756-5p ; hsa-mir-4739 ; hsa-mir-1321 ; hsa-mir-449c-5p ; hsa-mir-34b-5p ; hsa-mir-2682-5p ; hsa-mir-3714 ; hsa-mir-129-5p ; hsa-mir-8055 ; hsa-mir-8081

Nearest miRNA

hsa-mir-10392/Upstream/3753796; hsa-let-7a-2/Downstream/1439786;

Nearest TSS

Nearest CpG islands

None/Target, chr11-CpG: 30/Upstream/24878, chr11-CpG: 57/Downstream/27843

Nearest cancer related gene

TAGLN(TSG, No orient, 0)

Upstream sequence

TTTACTatcatacatcataggattttagagctagaagggtctttagaatgtaactagtccaatgtcctcattttgtacatggaaaaaataagctggaggt

Downstream sequence

GAAAGCGCAGGAGCATAAGAGGGAATTCACAGAGAGCCAGCTGCAGGAGGGAAAGCATGTCATTGGCCTTCAGATGGGCAGCAACAGAGGGGCCTCCCAG

Target sequence

GTATGTGGCCCCCAGGGAGCTTGGGTCTCCGCATGGGGTGGGAGGTGGCTTGTTCTAAGGAGCTTGCGGGAAGGATTAGGGGAAGCAGATAGCCAAGAAAGGATAAAGTGAGGGTCTGGGATGGGGAATAATGGGTCCTTAATACTCCTTGACCCCTCCCTTTCCACCCTCCTGCGCTCAGTCTCCCTAGCCTATGAGGCAAGCTAGATTAGGGAAAAAAAGTGCAACAGGAAGGCAATGGGATTGGGCTAGGAC