Basic Information
VIS ID
TVIS10018488
Fusion event
HBV-chr21 integration
Validated
No
Detection method
VirusFinder
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2017
PubMed ID
29212479
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1819
Integrated sequence
TTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGC| |AACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTA
Host Sequence
Chromosome
chr21
Cytoband
q21.2
Reference genome
GRCh37.55
Start
24032146/22659826 (Hg38)
End
24032150/22659830 (Hg38)
Nearest miRNA
hsa-let-7c/Upstream/3973662; hsa-mir-155/Downstream/419454;
Nearest TSS
ENST00000624081/Upstream/139768; ENST00000421604/Downstream/405661;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/1661581, chr21-CpG: 28/Downstream/2701964
Nearby gene
LINC00308
Upstream sequence
ACACAGCTGCATGAATTTACTTAGTTGACTTGCCTTGGGAGGATAAATCCCCTGATAAAATGGGGCATATGGGGTGAACATTTAATTGGGATTGAGGTGA
Downstream sequence
AGGACAGTAGACCCAGGTAAAAATATATTAAAGAATTAGCCATGTTCATACACAAATACAAATGAAAACGTCCTCTTTGGCTGGCTTTATAGTGAGAGAT
Target sequence
TTTA
Reference
Yoo, S., et al. A pilot systematic genomic comparison of recurrence risks of hepatitis B virus-associated hepatocellular carcinoma with low- and high-degree liver fibrosis. BMC Med ,2017, 15(1): 214.
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