VISDB Viral Integration Site DataBase

VIS ID

TVIS10018496

Fusion event

HBV-PPP2CA integration

Validated

No

Detection method

VirusFinder

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2017

PubMed ID

Virus name

HBV

Reference genome

Start

58

End

157

Integrated sequence

CTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACAT

Chromosome

chr5

Cytoband

q31.1

Reference genome

Start

End

133533534/134197843 (Hg38)

Location type

Exon1

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-340-3p ; hsa-mir-197-3p ; hsa-mir-153-5p ; hsa-mir-4777-5p ; hsa-mir-526a ; hsa-mir-523-5p ; hsa-mir-522-5p ; hsa-mir-520c-5p ; hsa-mir-519c-5p ; hsa-mir-519b-5p ; hsa-mir-519a-5p ; hsa-mir-518f-5p ; hsa-mir-518e-5p ; hsa-mir-518d-5p ; hsa-mir-4766-3p ; hsa-mir-3152-3p ; hsa-mir-4305 ; hsa-mir-889-3p ; hsa-mir-107 ; hsa-mir-103a-3p ; hsa-mir-545-3p ; hsa-mir-96-3p ; hsa-mir-5583-3p ; hsa-mir-4517 ; hsa-mir-3646 ; hsa-mir-548c-3p ; hsa-mir-8081 ; hsa-mir-6869-5p ; hsa-mir-185-3p ; hsa-mir-4283 ; hsa-mir-4656 ; hsa-mir-4489 ; hsa-mir-5186 ; hsa-mir-3675-5p ; hsa-mir-9500 ; hsa-mir-6822-5p ; hsa-mir-6750-5p ; hsa-mir-5584-5p ; hsa-mir-548g-3p ; hsa-mir-548av-3p ; hsa-mir-630 ; hsa-mir-4670-3p ; hsa-mir-7705 ; hsa-mir-522-3p ; hsa-mir-224-3p ; hsa-mir-4694-3p ; hsa-mir-6079 ; hsa-mir-584-5p ; hsa-mir-92a-1-5p ; hsa-mir-671-5p ; hsa-mir-6828-5p ; hsa-mir-758-5p ; hsa-mir-218-2-3p ; hsa-mir-33a-3p ; hsa-mir-670-5p ; hsa-mir-4732-3p ; hsa-mir-345-3p ; hsa-mir-3133 ; hsa-mir-553 ; hsa-mir-188-5p ; hsa-mir-4319 ; hsa-mir-6866-3p ; hsa-mir-125b-5p ; hsa-mir-125a-5p ; hsa-mir-186-3p ; hsa-mir-216a-5p ; hsa-mir-513c-5p ; hsa-mir-514b-5p ; hsa-mir-548as-3p ; hsa-mir-548u ; hsa-mir-7161-5p ; hsa-mir-8087

Nearest miRNA

hsa-mir-10397/Upstream/770018; hsa-mir-103a-1/Downstream/27914;

Nearest TSS

Nearest CpG islands

None/Target, chr5-CpG: 87/Upstream/20295, chr5-CpG: 140/Downstream/27606

Nearest cancer related gene

PPP2CA(TSG, No orient, 0)

Upstream sequence

ATGTTTAATAGTTTATAATTTAATAAACTTAGATcagtgattctcaaaccagggcaaccgctttcccctccaacacatacacatgctaagggacatttga

Downstream sequence

GCTGAAAAACAAGACCGATTCATGGTTTATGTTCCACGACCTCCATGTAGTGACAATCAAGATCAAGAACATGAGTCTTCCAAACTTTACACTTCCTATT

Target sequence

AGGTCGATATATGGTTCATGGCAATACTGTACAAGTTTAAAATTTCATTACAGGAAGTAGTCTGGGGTACGACGAGTAACATGTGGCTCGCCTCTACGAGGTGCTGGGTCAAACTGCAA