Basic Information
VIS ID
TVIS10018506
Fusion event
HBV-chr16 integration
Validated
No
Detection method
VirusFinder
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29212479
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1406
Integrated sequence
CAGGTCTGGAGCAAACATTATCGGGACTGATAACTCTGTTGTCCTATCCCGCAAATATACATCGTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATC| |CTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCCTGCGGACGACCCTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGC
Host Sequence
Chromosome
chr16
Cytoband
p13.11
Reference genome
GRCh37.55
Start
14805864/14712007 (Hg38)
End
14805864/14712007 (Hg38)
Location type
Intron
Target gene
NPIPA2 ; NPIPA3
Nearest miRNA
hsa-mir-1225/Upstream/402636; hsa-mir-11401/Downstream/189501;
Nearest TSS
ENST00000527434/Upstream/318; ENST00000530328/Downstream/34170;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/8209, chr16-CpG: 21/Downstream/21331
Upstream sequence
tgcaaggcaactggaactctcataaaaatggtagagaatagagaactacatacacataaaacattaaaaaacgtgtaaatctgagtaagtcccatgtaca
Downstream sequence
ACCACCGGGGTCATCAGGGATTGGTGGAGAGAGAGTCTAAAGCCCCAGGGTTGCTAAGGGAGGGCCCAGACCGAAGAAGGTTTGGTGGAAAGCAGAACCT
Reference
Yoo, S., et al. A pilot systematic genomic comparison of recurrence risks of hepatitis B virus-associated hepatocellular carcinoma with low- and high-degree liver fibrosis. BMC Med ,2017, 15(1): 214.
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