Basic Information
VIS ID
TVIS10018510
Fusion event
HBV-chr21 integration
Validated
No
Detection method
VirusFinder
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29212479
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
541
End
640
Integrated sequence
AAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCT
Host Sequence
Chromosome
chr21
Cytoband
p11.2
Reference genome
GRCh37.55
Start
11035597/10476858 (Hg38)
End
11035597/10476858 (Hg38)
Location type
Intron
Target gene
BAGE2 ; BAGE3 ; BAGE4 ; BAGE5
miRNAs that regulate target gene
hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-93-5p ; hsa-mir-17-5p
Nearest miRNA
hsa-mir-10396a/Upstream/1489193; hsa-let-7c/Downstream/2929526;
Nearest TSS
ENST00000624081/Upstream/134121; ENST00000612957/Downstream/44695;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/71120, chr21-CpG: 159/Downstream/44185
Upstream sequence
TTGCTGTCTGTTACTTCTACCTTATCATGTCTAATTTTTCCTCATCTTTGTGAAATCCTGCATCTATTGTAATAGGCAAAAAAAACAAAAAACAAAAGGA
Downstream sequence
ATCTTATTCTATTCACAGCCATCAGAAAAATGTGTTACTATTCCTGTAGTCAGGTTCTAAATCATACATTTGAGATATATCTCAAACATGTCATAAAGAA
Reference
Yoo, S., et al. A pilot systematic genomic comparison of recurrence risks of hepatitis B virus-associated hepatocellular carcinoma with low- and high-degree liver fibrosis. BMC Med ,2017, 15(1): 214.
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