Basic Information
VIS ID
TVIS10018519
Fusion event
HBV-chr3 integration
Validated
No
Detection method
VirusFinder
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29212479
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
6
End
177
Integrated sequence
ACAACCTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGAT
Host Sequence
Chromosome
chr3
Cytoband
q25.33
Reference genome
GRCh37.55
Start
159563736/159845947 (Hg38)
End
159563736/159845947 (Hg38)
Location type
Intron
Fragile sites / regions
FRA3D
Target gene
IQCJ-SCHIP1 ; LOC101928351 ; SCHIP1
miRNAs that regulate target gene
hsa-mir-98-5p
Nearest miRNA
hsa-let-7g/Upstream/563213; hsa-mir-1224/Downstream/558641;
Nearest TSS
ENST00000440867/Upstream/5848; ENST00000475932/Downstream/6992;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/80713, chr3-CpG: 52/Downstream/142756
Upstream sequence
tgtagacttgtgcatatcttgggtgagtatatgtgcactattctgttgagtatatcaaggaggaatttctagctcataaggtacacacatagttagattt
Downstream sequence
AAACATCTCATGTGCCAGAATTGGGGGTGCAGTGCAAGGCACAAAATAAATGAATGACTGGGATGCACAGACATTCCAGCCTTCCCAGAGACAATGCATT
Reference
Yoo, S., et al. A pilot systematic genomic comparison of recurrence risks of hepatitis B virus-associated hepatocellular carcinoma with low- and high-degree liver fibrosis. BMC Med ,2017, 15(1): 214.
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