Basic Information
VIS ID
TVIS10018521
Fusion event
HBV-chr4 integration
Validated
No
Detection method
VirusFinder
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29212479
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1813
Integrated sequence
AGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCA| |CCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGA
Host Sequence
Chromosome
chr4
Cytoband
q13.3
Reference genome
GRCh37.55
Start
74269998/73404281 (Hg38)
End
74269998/73404281 (Hg38)
Location type
Exon1
Target gene
ALB ; LOC111832671
miRNAs that regulate target gene
hsa-mir-492
Nearest miRNA
hsa-mir-12113/Upstream/7127353; hsa-mir-1243/Downstream/3169287;
Nearest TSS
ENST00000502981/Upstream/26; ENST00000510166/Downstream/6;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/144868, chr4-CpG: 20/Downstream/216046
Upstream sequence
TAAGTCATTGTGTAATGAGAGAATTTGGAAATGAAGGTGAAGGAGAAATATTCAAAGAAAAGTCATCCAAGGAAGGAAGAAATTCTATCGGTCATACAAA
Downstream sequence
TTGTCCTAGCTTTTCTCTTCTGTCAACCCCACACGCCTTTGGCACAATGAAGTGGGTAACCTTTATTTCCCTTCTTTTTCTCTTTAGCTCGGCTTATTCC
Reference
Yoo, S., et al. A pilot systematic genomic comparison of recurrence risks of hepatitis B virus-associated hepatocellular carcinoma with low- and high-degree liver fibrosis. BMC Med ,2017, 15(1): 214.
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