EWSR1 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10018549
Fusion event
HBV-EWSR1 integration
Validated
No
Detection method
VirusFinder
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29212479
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1824
Integrated sequence
TTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTT| |TTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAG
Host Sequence
Chromosome
chr22
Cytoband
q12.2
Reference genome
GRCh37.55
Start
29683202/29287213 (Hg38)
End
29683202/29287213 (Hg38)
Location type
Intron7
Target gene
EWSR1
miRNAs that regulate target gene
hsa-let-7a-5p ; hsa-mir-877-3p ; hsa-mir-615-3p ; hsa-mir-423-3p ; hsa-mir-328-3p ; hsa-mir-362-5p ; hsa-mir-320a ; hsa-mir-149-5p ; hsa-mir-23b-3p ; hsa-mir-196a-5p ; hsa-mir-100-5p ; hsa-let-7c-5p
Nearest miRNA
hsa-mir-1286/Upstream/827265; hsa-let-7a-3/Downstream/719836;
Nearest TSS
ENST00000624155/Upstream/11584; ENST00000610553/Downstream/3617;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/18299, chr22-CpG: 164/Downstream/19119
Nearest cancer related gene
EWSR1(OG, No orient, 0)
Upstream sequence
GCAGCAGCTACGGGCAGCAGAGTGAGTTGCTAAGAGAGAAAACCAAATAAGAATGAATGTGTTTAGAGTTTTTTTGTGGGGTTGAttttttttgttggtt
Downstream sequence
tgtttttcttttgagatggagtttcactcttggggctgaggctggagtacagtggtgccatctcagctcactgcagcctccgcctcctggttcaagcaat
Reference
Yoo, S., et al. A pilot systematic genomic comparison of recurrence risks of hepatitis B virus-associated hepatocellular carcinoma with low- and high-degree liver fibrosis. BMC Med ,2017, 15(1): 214.
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