Basic Information
VIS ID
TVIS10018564
Fusion event
HBV-chr19 integration
Validated
No
Detection method
VirusFinder
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2017
PubMed ID
29212479
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
762
Integrated sequence
TTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGG| |CCAAGTCTGTACAGCATCTTGAGTCCCTTTTTACCGCTGTTACCAATTTTCTTTTGTCTTTGGGTATACATTTAAACCCTAACAAAACAAAGAGATGGGG
Host Sequence
Chromosome
chr19
Cytoband
p13.3
Reference genome
GRCh37.55
Start
4682409/4682397 (Hg38)
End
4682444/4682432 (Hg38)
Location type
Intron
Fragile sites / regions
FRA19B
Target gene
DPP9 ; DPP9-AS1
miRNAs that regulate target gene
hsa-mir-106b-5p ; hsa-mir-5089-5p ; hsa-mir-4279 ; hsa-mir-4423-3p ; hsa-mir-6778-3p ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-4740-3p ; hsa-mir-1295b-3p ; hsa-mir-3622a-5p ; hsa-mir-5582-5p ; hsa-mir-106a-5p ; hsa-mir-150-5p ; hsa-mir-17-5p ; hsa-mir-186-3p ; hsa-mir-20a-5p ; hsa-mir-20b-5p ; hsa-mir-302a-3p ; hsa-mir-302b-3p ; hsa-mir-302c-3p ; hsa-mir-302d-3p ; hsa-mir-302e ; hsa-mir-372-3p ; hsa-mir-373-3p ; hsa-mir-4707-3p ; hsa-mir-4731-5p ; hsa-mir-512-3p ; hsa-mir-519d-3p ; hsa-mir-520a-3p ; hsa-mir-520b ; hsa-mir-520c-3p ; hsa-mir-520d-3p ; hsa-mir-520e ; hsa-mir-520g-3p ; hsa-mir-520h ; hsa-mir-526b-3p ; hsa-mir-5589-5p ; hsa-mir-6504-3p ; hsa-mir-93-5p ; hsa-mir-2681-5p ; hsa-mir-4445-5p ; hsa-mir-5087 ; hsa-mir-627-3p ; hsa-mir-8068 ; hsa-mir-876-3p
Nearest miRNA
hsa-mir-1227/Upstream/236349; hsa-let-7e/Downstream/88238;
Nearest TSS
ENST00000633603/Upstream/3115; ENST00000591008/Downstream/2378;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/5691, chr19-CpG: 61/Downstream/282
Upstream sequence
atcgtctctatctccagaagaggcccagaatctaaccacttctctccacttccactgtctccattctgctccgagctaccgttactcctcacctgcatca
Downstream sequence
AGGGCTGTGAGCCTCCTTCCCCAGACAAGCATCCCTGGGTGCCCCTTCCTGCAAGGTGCAGTGAGGAGGGAGGGTGGGCTGGAGGGGACTGTGAGGCACA
Target sequence
AGCAGTGACTCGAATTCCCTCATCTTTCCCAGGGC
Reference
Yoo, S., et al. A pilot systematic genomic comparison of recurrence risks of hepatitis B virus-associated hepatocellular carcinoma with low- and high-degree liver fibrosis. BMC Med ,2017, 15(1): 214.
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