Basic Information
VIS ID
TVIS10018584
Fusion event
HBV-chr20 integration
Validated
No
Detection method
VirusFinder
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2017
PubMed ID
29212479
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
921
End
1562
Integrated sequence
ACATCATACAAAAAATCAAAGAATGTTTTAGAAAACTTCCTATTAACAGGCCTATTGATTGGAAAGTATGTCAACGAATTGTGGGTCTTTTGGGTTTTGCTGCCCCTTTTACACAATGTGGTTATCCTGCGTTGATGCCTTTGTATGCATGTATTCAATCTAAGCAGGCTTTCACTTTCTCGCCAACTTACAAGGCCTTTCTGTGTAAACAATACCTGAACCTTTACCCCGTTGCCCGGCAACGGCCAGGTCTGT
Host Sequence
Chromosome
chr20
Cytoband
q12
Reference genome
GRCh37.55
Start
39435032/40806392 (Hg38)
End
39435041/40806401 (Hg38)
Nearest miRNA
hsa-mir-103a-2/Upstream/2289760; hsa-mir-1-1/Downstream/362622;
Nearest TSS
ENST00000382410/Upstream/107776; ENST00000361337/Downstream/222417;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/113385, chr20-CpG: 150/Downstream/222020
Nearby gene
MAFB
Nearest cancer related gene
MAFB(OG, No orient)
Upstream sequence
tggggattaggatgtggttatccttgggtgagggacattattctgcctcccataCTGAATCCAAAGGGCTTAGATAATGCAGAACAAATTCACAACTTTA
Downstream sequence
GCCACTCCTGCCCTGGAGCAGTAATGCACATGTATATTTGTAGGTGTGCACTTATCATCTCTCCCCCATCCCAGCATGCTGAGAACGCTAACCCTTGCTG
Target sequence
GCCATTCCA
Reference
Yoo, S., et al. A pilot systematic genomic comparison of recurrence risks of hepatitis B virus-associated hepatocellular carcinoma with low- and high-degree liver fibrosis. BMC Med ,2017, 15(1): 214.
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