Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene35777010357180193573887835704527357170383566651635678483357101993572018635667948356732913570180135703400356727193567382135689923356903183569385935694048356969793569712835721763
hsa-mir-1294 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10018585
Fusion event
HBV-KMT2B integration
Validated
No
Detection method
VirusFinder
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29212479
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1955
Integrated sequence
GTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTT| |TTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCAC
Host Sequence
Chromosome
chr19
Cytoband
q13.12
Reference genome
GRCh37.55
Start
36212665/35721763 (Hg38)
End
36212665/35721763 (Hg38)
Location type
Exon3
Fragile sites / regions
FRA19A
Target gene
KMT2B
miRNAs that regulate target gene
hsa-mir-7515 ; hsa-mir-302a-5p ; hsa-mir-3154 ; hsa-mir-6782-3p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-5692a ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-106a-5p ; hsa-mir-20b-5p ; hsa-mir-153-3p ; hsa-mir-1224-3p ; hsa-mir-1294 ; hsa-mir-1914-3p ; hsa-mir-214-3p ; hsa-mir-31-5p ; hsa-mir-3184-5p ; hsa-mir-3619-5p ; hsa-mir-3689d ; hsa-mir-423-5p ; hsa-mir-4316 ; hsa-mir-4426 ; hsa-mir-4440 ; hsa-mir-4459 ; hsa-mir-4647 ; hsa-mir-4662b ; hsa-mir-4688 ; hsa-mir-4722-5p ; hsa-mir-5194 ; hsa-mir-6085 ; hsa-mir-6165 ; hsa-mir-6734-5p ; hsa-mir-6738-5p ; hsa-mir-6743-5p ; hsa-mir-6789-5p ; hsa-mir-6813-5p ; hsa-mir-6851-5p ; hsa-mir-761 ; hsa-mir-7704 ; hsa-mir-885-3p
Nearest miRNA
hsa-mir-10395/Upstream/376136; hsa-let-7e/Downstream/3687860;
Nearest TSS
ENST00000633603/Upstream/861; ENST00000592092/Downstream/11495;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/1739, chr19-CpG: 24/Downstream/1963
Upstream sequence
CAGGCAGCAGAATATAGTGGTTATAGGAACACAGGTGGAAACCCTGTCCAAAGCAAGGGCTATCGGGTATCACCTCTGACCATCCTTCCCATTCATCCTC
Downstream sequence
TCGATCAGCAGCAGCAGCAGAAGGTGGCAGCTTCCATGCCGGTGAGTGTGGTCCCTGGGCCCAGCGGCACACCCAGCCATCCAGCCTCCATTCTTTGCAA
Reference
Yoo, S., et al. A pilot systematic genomic comparison of recurrence risks of hepatitis B virus-associated hepatocellular carcinoma with low- and high-degree liver fibrosis. BMC Med ,2017, 15(1): 214.
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