Basic Information
VIS ID
TVIS10018609
Fusion event
HBV-chr4 integration
Validated
No
Detection method
VirusFinder
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29212479
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1797
Integrated sequence
TTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATT| |GGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTT
Host Sequence
Chromosome
chr4
Cytoband
q35.1
Reference genome
GRCh37.55
Start
184453700/183532547 (Hg38)
End
184453700/183532547 (Hg38)
Nearest miRNA
hsa-mir-12113/Upstream/1363169; hsa-mir-3945/Downstream/1318466;
Nearest TSS
ENST00000502981/Upstream/15653; ENST00000504526/Downstream/123549;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/26072, chr4-CpG: 85/Downstream/126221
Nearby gene
ING2
Nearest cancer related gene
ING2(TSG, No orient)
Upstream sequence
CACAAAGACATATTCACCACTTGGCAAATGTCACAACCCCAACACAAACCATGAACTACCAGAAGGCAAGCAGTAAGTCCCACATTTTTCACCACCATGT
Downstream sequence
AGAACTAGTGTATGGCTCTGATTTGTGCGTAGCATGCTCTGTTGTTATATTTAAAGTACGACTGCTAAATTCATTATTTGGGAATTGTTACAAGATGTGG
Reference
Yoo, S., et al. A pilot systematic genomic comparison of recurrence risks of hepatitis B virus-associated hepatocellular carcinoma with low- and high-degree liver fibrosis. BMC Med ,2017, 15(1): 214.
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