Basic Information
VIS ID
TVIS10018614
Fusion event
HBV-RIPOR2 integration
Validated
No
Detection method
VirusFinder
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29212479
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1821
Integrated sequence
TGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAA| |CTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATA
Host Sequence
Chromosome
chr6
Cytoband
p22.3
Reference genome
GRCh37.55
Start
25016566/25016338 (Hg38)
End
25016566/25016338 (Hg38)
Location type
Intron13
Target gene
RIPOR2
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-374a-5p ; hsa-mir-4674 ; hsa-mir-4314 ; hsa-mir-6749-3p ; hsa-mir-1260b ; hsa-mir-1260a ; hsa-mir-4437 ; hsa-mir-6778-3p ; hsa-mir-378g ; hsa-mir-4486 ; hsa-mir-6860 ; hsa-mir-612 ; hsa-mir-5189-5p ; hsa-mir-3187-5p ; hsa-mir-1285-3p ; hsa-mir-532-3p ; hsa-mir-1224-3p ; hsa-mir-6877-3p ; hsa-mir-6819-3p
Nearest miRNA
hsa-mir-3691/Upstream/6444458; hsa-mir-10398/Downstream/2131288;
Nearest TSS
ENST00000381078/Upstream/80286; ENST00000428903/Downstream/25501;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/104980, chr6-CpG: 36/Downstream/123354
Upstream sequence
tgtagcattccttcctctgaggtatggacaacacccctctggaatgaagatcttcaagggaaaagggagaggggaaagacctttctagactttatggctt
Downstream sequence
GCTGGATCCCTGAAGCTAATCTCAGCGATTTAAAGTAGAGAATAAGGATGGAATGCATCCCCTCCATTAGTCTTGAAGTGAAACCACAGGAACTCTATTC
Reference
Yoo, S., et al. A pilot systematic genomic comparison of recurrence risks of hepatitis B virus-associated hepatocellular carcinoma with low- and high-degree liver fibrosis. BMC Med ,2017, 15(1): 214.
Curate