EIF2B1 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10018637
Fusion event
HBV-EIF2B1 integration
Validated
No
Detection method
VirusFinder
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2017
PubMed ID
29212479
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1751
Integrated sequence
TTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGG| |AGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGT
Host Sequence
Chromosome
chr12
Cytoband
q24.31
Reference genome
GRCh37.55
Start
124112927/123628380 (Hg38)
End
124112932/123628385 (Hg38)
Location type
Intron5
Fragile sites / regions
FRA12E
Target gene
EIF2B1
miRNAs that regulate target gene
hsa-mir-30a-5p ; hsa-mir-26b-5p ; hsa-mir-1228-3p ; hsa-mir-30b-5p ; hsa-mir-218-5p ; hsa-mir-1277-5p ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-410-3p ; hsa-mir-6796-3p ; hsa-mir-99b-3p ; hsa-mir-99a-3p ; hsa-mir-493-5p ; hsa-mir-656-3p ; hsa-mir-5580-3p
Nearest miRNA
hsa-let-7i/Upstream/91846; hsa-mir-3612/Downstream/708796;
Nearest TSS
ENST00000382841/Upstream/10364; ENST00000543005/Downstream/4062;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/25912, chr12-CpG: 43/Downstream/5165
Upstream sequence
TCTGAATAAACAGAAGTGACATTAATTATGATTTTATACATATAAATGAGCAAAGTGGAAATAAATCCAAGGCATTAATGGGCCCATAAATGTTGTGTTT
Downstream sequence
ggatctcactccaattgcccaggctgaagtgcagtggtatgatctcagctcactgcagcctcaacttcctgggttcaggtgattctcccacctgagcctc
Target sequence
agaca
Reference
Yoo, S., et al. A pilot systematic genomic comparison of recurrence risks of hepatitis B virus-associated hepatocellular carcinoma with low- and high-degree liver fibrosis. BMC Med ,2017, 15(1): 214.
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