Basic Information
VIS ID
TVIS10018681
Fusion event
HBV-COP1 integration
Validated
No
Detection method
VirusFinder
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29212479
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1826
Integrated sequence
AAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTT| |TCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAA
Host Sequence
Chromosome
chr1
Cytoband
q25.1
Reference genome
GRCh37.55
Start
176001302/176032166 (Hg38)
End
176001302/176032166 (Hg38)
Location type
Intron6
Target gene
COP1
miRNAs that regulate target gene
hsa-mir-24-3p ; hsa-mir-1180-3p ; hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-15a-5p ; hsa-mir-15b-5p
Nearest miRNA
hsa-mir-101-1/Upstream/63687; hsa-mir-1182/Downstream/997197;
Nearest TSS
ENST00000473358/Upstream/14889; ENST00000456125/Downstream/49090;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/432494, chr1-CpG: 108/Downstream/174409
Nearest cancer related gene
COP1(TSG, No orient, 0)
Upstream sequence
TTTTCTTATTTTTTGGCACATGGCCCAAAATGTTAACAGTTGGAGATTCAAGTGAGATAATTTGAAAATGCAACACTCCTGGTGGGATTAAACAGACTAT
Downstream sequence
CCATCATTAGTCTCAGTAAATGAATTTTTTAAATCAGATTGTTTTCTCATCACAAAATTTAAATCTGTCCAAGAAAAGAGAAAATGCTAGTTTGGGTATA
Reference
Yoo, S., et al. A pilot systematic genomic comparison of recurrence risks of hepatitis B virus-associated hepatocellular carcinoma with low- and high-degree liver fibrosis. BMC Med ,2017, 15(1): 214.
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