GLI3 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10018698
Fusion event
HBV-GLI3 integration
Validated
No
Detection method
VirusFinder
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2017
PubMed ID
29212479
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
2944
Integrated sequence
ACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTG| |GGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCGGGCTGGGTTTCACCCCACCGCACGGAGGCCTTTTGGGG
Host Sequence
Chromosome
chr7
Cytoband
p14.1
Reference genome
GRCh37.55
Start
42239937/42200338 (Hg38)
End
42239955/42200356 (Hg38)
Location type
Intron13
Target gene
GLI3
miRNAs that regulate target gene
hsa-mir-1301-3p ; hsa-mir-148b-3p ; hsa-mir-93-5p ; hsa-mir-200c-3p ; hsa-mir-378a-3p ; hsa-mir-506-3p ; hsa-mir-133b
Nearest miRNA
hsa-mir-1183/Upstream/5280906; hsa-mir-10399/Downstream/950539;
Nearest TSS
ENST00000635602/Upstream/47885; ENST00000432845/Downstream/27365;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/233815, chr7-CpG: 163/Downstream/36048
Nearest cancer related gene
GLI3(OG, No orient, 0)
Upstream sequence
tctcactctgttgcccaggctggagtgcagtggcgtgatcttgggctcactgcaacctccacctcctgggttcaagcaactctcttgcctcagcctccca
Downstream sequence
ACAGGAAAAAGGTAAAAGGAAtgaaggaaagagactttgaggccttatccttcaaatatttgtaagtacttgcggaagaagaattagcactaactcatgt
Target sequence
CATTCAAAGCCAACTCAG
Reference
Yoo, S., et al. A pilot systematic genomic comparison of recurrence risks of hepatitis B virus-associated hepatocellular carcinoma with low- and high-degree liver fibrosis. BMC Med ,2017, 15(1): 214.
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