ACACB _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10018709
Fusion event
HBV-ACACB integration
Validated
No
Detection method
VirusFinder
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29212479
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1819
Integrated sequence
TTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGC| |AACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTA
Host Sequence
Chromosome
chr12
Cytoband
q24.11
Reference genome
GRCh37.55
Start
109636133/109198328 (Hg38)
End
109636133/109198328 (Hg38)
Location type
Intron16
Fragile sites / regions
FRA12E
Target gene
ACACB
miRNAs that regulate target gene
hsa-mir-148b-3p ; hsa-mir-544a ; hsa-mir-7703 ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-4252 ; hsa-mir-6797-3p ; hsa-mir-6076 ; hsa-mir-4793-3p ; hsa-mir-766-3p ; hsa-mir-6849-3p ; hsa-mir-1273g-3p ; hsa-mir-425-5p ; hsa-mir-596 ; hsa-mir-508-5p
Nearest miRNA
hsa-let-7i/Upstream/361322; hsa-mir-1178/Downstream/635020;
Nearest TSS
ENST00000382841/Upstream/6850; ENST00000542524/Downstream/34341;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/43500, chr12-CpG: 19/Downstream/93439
Upstream sequence
TTGCACGTCTCTAGTGTTCTCTTATTCTATTCAGCAACTCTCTAGCTATTGCCCTAATTCCCCAGCTTGACTCACAAGCAAGACCTGCACGTTTCATCTC
Downstream sequence
ggaagacaccacATGTGGTCTGATGTCTCTTCAAATATTTAAACCTCgatttcccaaatcactcaaaatgaaatccaaatttgttcatgtggcctggtac
Reference
Yoo, S., et al. A pilot systematic genomic comparison of recurrence risks of hepatitis B virus-associated hepatocellular carcinoma with low- and high-degree liver fibrosis. BMC Med ,2017, 15(1): 214.
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