hsa-mir-130b-3p _LIHC.png
TCF4 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10018715
Fusion event
HBV-TCF4 integration
Validated
No
Detection method
VirusFinder
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29212479
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1817
Integrated sequence
TGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCAT| |GCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCT
Host Sequence
Chromosome
chr18
Cytoband
q21.2
Reference genome
GRCh37.55
Start
52916311/55249080 (Hg38)
End
52916311/55249080 (Hg38)
Location type
Intron5
Fragile sites / regions
FRA18B
Target gene
TCF4
miRNAs that regulate target gene
hsa-mir-204-5p ; hsa-mir-130b-3p ; hsa-mir-19b-3p ; hsa-let-7e-5p ; hsa-mir-203a-3p ; hsa-mir-452-5p ; hsa-mir-126-3p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-155-5p ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-20b-5p ; hsa-mir-17-5p ; hsa-mir-181a-5p
Nearest miRNA
hsa-mir-1-2/Upstream/2011890; hsa-mir-122/Downstream/230141;
Nearest TSS
ENST00000575820/Upstream/20125; ENST00000587660/Downstream/8415;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/289462, chr18-CpG: 80/Downstream/338742
Nearest cancer related gene
TCF4(TSG, No orient, 0)
Upstream sequence
tttataattgtcacaaaatgaataaaatacctagtactacacctaaccatggaggtgaaagatctatacaatgataattataaaatactgctgaaagaaa
Downstream sequence
catggtttggtcacttccccttcctaggccttagtcttcaaagaagggcaatgggctgatttccagggtacttttagaatctaaaattcAGTGGTCTGAG
Reference
Yoo, S., et al. A pilot systematic genomic comparison of recurrence risks of hepatitis B virus-associated hepatocellular carcinoma with low- and high-degree liver fibrosis. BMC Med ,2017, 15(1): 214.
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