Basic Information
VIS ID
TVIS10018719
Fusion event
HBV-ADA2 integration
Validated
No
Detection method
VirusFinder
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29212479
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1544
Integrated sequence
GAATCCTGCGGACGACCCTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCG| |GACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCC
Host Sequence
Chromosome
chr22
Cytoband
q11.1
Reference genome
GRCh37.55
Start
17694463/17213573 (Hg38)
End
17694463/17213573 (Hg38)
Location type
Intron9
Target gene
ADA2
miRNAs that regulate target gene
hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-450a-1-3p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-6788-5p ; hsa-mir-1273h-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-3656 ; hsa-mir-1251-3p ; hsa-mir-6087 ; hsa-mir-6089 ; hsa-mir-1825 ; hsa-mir-520f-3p ; hsa-mir-302c-3p ; hsa-mir-3622a-5p ; hsa-mir-3190-5p ; hsa-mir-3606-5p ; hsa-mir-3675-3p ; hsa-mir-377-5p ; hsa-mir-3926 ; hsa-mir-4537 ; hsa-mir-455-3p ; hsa-mir-4684-5p ; hsa-mir-4786-5p ; hsa-mir-4793-3p ; hsa-mir-548s ; hsa-mir-6086 ; hsa-mir-6499-3p ; hsa-mir-6516-5p ; hsa-mir-6771-3p ; hsa-mir-6849-3p ; hsa-mir-7703
Nearest miRNA
hsa-let-7a-3/Downstream/550607;
Nearest TSS
ENST00000624155/Upstream/3684; ENST00000497534/Downstream/5862;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/41485, chr22-CpG: 230/Downstream/155002
Upstream sequence
gtggcaAGTCCATCTACCGAAGCACCGGGGAGTGTCGTGGATGCCTACGAGCAGGTACAAAAAGGACTTCTAAAGCTGAAAGGCGTCGCAGAGCTCAGAG
Downstream sequence
TGACCAAGCGGAAGAAGAAAAAGAAGGACAAAGACAAAGCTAAACTCCCGGAATCAATGGGAATGAACAAAAAGAATGAGGAGGAGAAGCAGCACGGCCT
Reference
Yoo, S., et al. A pilot systematic genomic comparison of recurrence risks of hepatitis B virus-associated hepatocellular carcinoma with low- and high-degree liver fibrosis. BMC Med ,2017, 15(1): 214.
Curate