Basic Information
VIS ID
TVIS10018728
Fusion event
HBV-IGH integration
Validated
No
Detection method
VirusFinder
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29212479
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
458
Integrated sequence
CTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCA| |AGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTAT
Host Sequence
Chromosome
chr14
Cytoband
q32.33
Reference genome
GRCh37.55
Start
106500810/106044579 (Hg38)
End
106500810/106044579 (Hg38)
Location type
Intronic
Target gene
IGH
Nearest miRNA
hsa-mir-1185-1/Upstream/185026; hsa-mir-5195/Downstream/806306;
Nearest TSS
ENST00000550708/Upstream/4815; ENST00000605005/Downstream/1281;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/176518, chr14-CpG: 17/Downstream/169257
Nearby gene
ADAM6
Upstream sequence
GGGTTTCTGATGTCAAGTTGAGGCACTCCCTTTCTAAGAGCTGGATTTTTAATTACATGGGTATTTATGGGCTCCCTGTGTGGAAATAAGCCTTGTCTAT
Downstream sequence
AGGAGACTGAGGAAGACAAAAGGATTTGACAGAAGGGAAGGTGGAGAAACAGTGTGAAGAGCAGAAGACCAGAACCCAACCAAAGTGGAGGAACTGACCC
Reference
Yoo, S., et al. A pilot systematic genomic comparison of recurrence risks of hepatitis B virus-associated hepatocellular carcinoma with low- and high-degree liver fibrosis. BMC Med ,2017, 15(1): 214.
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