Basic Information
VIS ID
TVIS10018732
Fusion event
HBV-chr4 integration
Validated
No
Detection method
VirusFinder
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29212479
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1571
End
1774
Integrated sequence
CCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTAC
Host Sequence
Chromosome
chr4
Cytoband
q26
Reference genome
GRCh37.55
Start
119180047/118258892 (Hg38)
End
119180047/118258892 (Hg38)
Location type
Intronic
Target gene
LOC105377392 ; NDST3
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-665 ; hsa-mir-7977 ; hsa-mir-4687-3p ; hsa-mir-7974 ; hsa-mir-4268 ; hsa-mir-1537-5p ; hsa-mir-3664-3p ; hsa-mir-4267 ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4768-3p ; hsa-mir-6736-3p ; hsa-mir-889-5p ; hsa-mir-4695-5p ; hsa-mir-1268a ; hsa-mir-1268b ; hsa-mir-323a-5p ; hsa-mir-548c-3p ; hsa-mir-876-3p ; hsa-mir-941
Nearest miRNA
hsa-mir-12113/Upstream/3602038; hsa-mir-1305/Downstream/7248367;
Nearest TSS
ENST00000502981/Upstream/224547; ENST00000602483/Downstream/19817;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/224840, chr4-CpG: 53/Downstream/19573
Nearby gene
SNHG8
Upstream sequence
ggctactttcacttaacataatgtctttgagattcataatgtcattgatatactattgtatataagtttaatctttttcattattgcctactcttctact
Downstream sequence
GGACCCTAGAATAAGAGAATAAGAGAATCACACAGCTGTTACTAAATGGACTTCAGAACAGGAATGATTATAGCATTTCTTACCCCTAGTATTCTGTTCT
Reference
Yoo, S., et al. A pilot systematic genomic comparison of recurrence risks of hepatitis B virus-associated hepatocellular carcinoma with low- and high-degree liver fibrosis. BMC Med ,2017, 15(1): 214.
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