IGF2BP2 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10018751
Fusion event
HBV-IGF2BP2 integration
Validated
No
Detection method
VirusFinder
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29212479
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1137
Integrated sequence
TGTGGTTATCCTGCGTTGATGCCTTTGTATGCATGTATTCAATCTAAGCAGGCTTTCACTTTCTCGCCAACTTACAAGGCCTTTCTGTGTAAACAATACC| |TGAACCTTTACCCCGTTGCCCGGCAACGGCCAGGTCTGTGCCAAGTGTTTGCTGACGCAACCCCCACTGGCTGGGGCTTGGTCATGGGCCATCAGCGCAT
Host Sequence
Chromosome
chr3
Cytoband
q27.2
Reference genome
GRCh37.55
Start
185511089/185793301 (Hg38)
End
185511089/185793301 (Hg38)
Location type
Intron14
Fragile sites / regions
FRA3C
Target gene
IGF2BP2
miRNAs that regulate target gene
hsa-mir-18a-5p ; hsa-let-7b-5p ; hsa-mir-335-5p ; hsa-mir-98-5p ; hsa-mir-877-5p ; hsa-mir-125a-3p ; hsa-mir-331-3p ; hsa-mir-129-5p ; hsa-mir-589-3p
Nearest miRNA
hsa-let-7g/Upstream/25397; hsa-mir-1248/Downstream/993371;
Nearest TSS
ENST00000440867/Upstream/65057; ENST00000453370/Downstream/27802;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/206592, chr3-CpG: 288/Downstream/29959
Upstream sequence
acacagtgtgtatatacatacacGTGTGtatatatatatacacacttgttcttatttaatgtatataatctttctagactagaaactacgtgagaacaga
Downstream sequence
gaacctcagtctcctcttctgaggaataaggctgccacacagggatgttgggagatcagtgatagcccacataaagcacctagcccagtAAAATGGTCTC
Reference
Yoo, S., et al. A pilot systematic genomic comparison of recurrence risks of hepatitis B virus-associated hepatocellular carcinoma with low- and high-degree liver fibrosis. BMC Med ,2017, 15(1): 214.
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