TUSC3 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10018759
Fusion event
HBV-TUSC3 integration
Validated
No
Detection method
VirusFinder
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29212479
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
2949
Integrated sequence
ATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACT| |TCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCGGGCTGGGTTTCACCCCACCGCACGGAGGCCTTTTGGGGTGGAG
Host Sequence
Chromosome
chr8
Cytoband
p22
Reference genome
GRCh37.55
Start
15454899/15597390 (Hg38)
End
15454899/15597390 (Hg38)
Location type
Intron1
Target gene
TUSC3
miRNAs that regulate target gene
hsa-mir-128-3p ; hsa-mir-26b-5p ; hsa-mir-1229-3p ; hsa-mir-25-3p ; hsa-mir-181a-5p ; hsa-mir-30e-5p
Nearest miRNA
hsa-mir-124-1/Upstream/743880; hsa-mir-10400/Downstream/2084188;
Nearest TSS
ENST00000518652/Upstream/35771; ENST00000509177/Downstream/25688;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/56612, chr8-CpG: 46/Downstream/1404145
Upstream sequence
TGCCAGCCCTTCCCGATGGCACCCCCTTTCCTCCTCCTCCTTGACATCCCTGAAAATGTTCACTGGGAGCAAATGAAAAAGCTTACGGTGGATGCTGAAT
Downstream sequence
CTTAAATATTAGTTGCTAGTATATGTATGTCTTTCGGTTATGCTTTGCTAATTTATTGAGAACATTGATGTATTTTTTCTTTGTCTTTCTTTAAATTATT
Reference
Yoo, S., et al. A pilot systematic genomic comparison of recurrence risks of hepatitis B virus-associated hepatocellular carcinoma with low- and high-degree liver fibrosis. BMC Med ,2017, 15(1): 214.
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